Síndrome antissintetase: anti-PL-7, anti-PL-12 e anti-EJ
نویسندگان
چکیده
منابع مشابه
Syndrome in question: antisynthetase syndrome (anti-PL-7)*
Antisynthetase syndrome is a rare autoimmune disease characterized by interstitial lung disease and/or inflammatory myositis, with positive antisynthetase antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, ZO, OJ, anti-KE or KS). Other symptoms described include: non-erosive arthritis, fever, Raynaud's phenomenon, and "mechanic's hands." The first therapeutic option is corticotherapy, followed by ot...
متن کاملClinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies.
OBJECTIVE The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings. METHODS Serum samples from 1,135 Japanese patients with various autoimmune diseases were screened for anti-PL-7 antibodies using RNA and protein immunopreci...
متن کاملAnnular erythema associated with Sjögren's syndrome preceding overlap syndrome of rheumatoid arthritis and polymyositis with anti-PL-12 autoantibodies.
A 44-year-old woman exhibited swelling with erythema on the bilateral upper eyelids. She was treated with prednisolone 20 mg/day at a different hospital. However, after the prednisolone was discontinued, the lesions relapsed. Four months after onset, the patient came to our clinic. A lip biopsy to investigate possible Sjögren’s syndrome (SS) confirmed lym phocytic infiltration of the minor sali...
متن کاملAnti-PL-7 (anti-threonyl-tRNA synthetase) antisynthetase syndrome: clinical manifestations in a series of patients from a European multicenter study (EUMYONET) and review of the literature.
Autoantibodies against several aminoacyl-transfer-RNA synthetases have been described in patients with myositis; anti-threonyl-tRNA synthetase (anti-PL-7) is one of the rarest. We describe the clinical and laboratory characteristics of a cohort of European anti-PL-7 patients, and compare them with previously reported cases. This multicenter study of patients positive for anti-PL-7, identified b...
متن کاملAnti-PL 4 in patients with systemic lupus erythematosus with severe renal and haematological disease.
Anti-PL 4 is an autoantibody which binds to a 150 kDa polypeptide and is found in approximately 1% of SLE sera. The clinical and laboratory features of 16 patients who have had anti-PL 4 detected in their serum are presented. Anti-PL 4 is highly specific for SLE (100%) and identifies a population of patients who typically develop severe renal (75%) and haematological disease (100%).
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ژورنال
عنوان ژورنال: Revista Brasileira de Reumatologia
سال: 2013
ISSN: 0482-5004
DOI: 10.1590/s0482-50042013000400007